一、基本信息

刘志华，博士，教授，博士生导师

电子邮箱：Zhihua_Liu(AT)hubu.edu.cn

研究领域：睡眠和近日节律行为的神经生物学机制。

本课题组通过开发新型遗传学工具和动物行为学分析方法，结合分子遗传学、细胞生物学、神经环路示踪、光遗传学和多组学等，重点解析：

1. 睡眠相位和入睡速度的分子调控机制。

2. 昼夜行为节律对环境变化的适应机制。

二、教育背景

2004.09–2011.07  中国科学院遗传与发育生物学研究所，发育生物学博士

2000.09–2004.07  兰州大学，理学学士

三、工作经历

2021.05至今        湖北大学生命科学院，教授

2013.2–2021.04  美国哈佛大学医学院神经生物学系，博士后

2011.08–2013.01  中国科学院遗传与发育生物学研究所，博士后

四、代表性论文（^#共同第一作者，^*共同通讯作者）

1. Zhou, B., Feng C., Sun S., Chen X., Zhuansun D., Wang D., Yu X., Meng X., Xiao J., Wu L., Wang J., Wang J., Chen K., Li Z., You J., Mao H., Yang S., Zhang J., Jiao C., Li Z., Yu D., Wu X., Zhu T., Yang J., Xiang L., Liu J., Chai T., Shen J., Mao C., Hu J., Hao X., Xiong B., Zheng S., Liu Z.,*, Feng J.* (2024) Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos. Developmental Cell. 10.1016/j.devcel.2024.03.034.

2. Mao, C.#, Hu, J.#, Bi, R, Luo, Y., Wu, K., Jin, S., Liu, Z., Jia, Y. (2024) The gut microbiome promotes locomotion of Drosophila larvae via octopamine signaling. Insect Science. DOI: 10.1111/1744-7917.13370

3. Niu, X.#, Mao, C.-X.#, Wang, S., Wang, X., Zhang, Y., Hu, J., Bi, R., Liu, Z*. and Shan, J. (2023). α-Tubulin acetylation at lysine 40 regulates dendritic arborization and larval locomotion by promoting microtubule stability in Drosophila. PLoS ONE 18, e0280573.

4. Gu L, Wang L, Chen H, Hong J, Shen Z, Dhall A, Lao T, Liu C, Wang Z, Xu Y, Tang HW, Chakraborty D, Chen J, Liu Z, Rogulja D, Perrimon N, Wu H, Shi Y. (2020) CG14906 (mettl4) mediates m(6)A methylation of U2 snRNA in Drosophila. Cell Discovery 6, 44.

5. Huang Y, Huang S, Lam SM, Liu Z, Shui G, Zhang YQ. (2016). Acsl, the Drosophila ortholog of intellectual disability-related ACSL4, inhibits synaptic growth by altered lipids. Journal of Cell Science 129, 4034–4045.

6. Liu Z^#, Huang Y^#, Hu W, Huang S, Wang Q, Han J, Zhang YQ. (2014). dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signalling via endocytic recycling. Journal of Neuroscience 34, 2785–2796.

7. Graf ER, Valakh V, Wright CM, Wu CL, Liu Z, Zhang YQ, DiAntonio A. (2012) RIM promotes calcium channel accumulation at active zones of the Drosophila neuromuscular junction. Journal of Neuroscience 32, 16586–16596.

8. Liu Z, Huang Y, Zhang Y, Chen D, Zhang YQ. (2011) Drosophila acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission. Journal of Neuroscience 31, 2052–2063.

9. Yao A, Jin S, Li X, Liu Z, Ma X, Tang J, Zhang YQ. (2011) Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria. Human Molecular Genetics 20, 51–63.

10. Jin S, Pan L, Liu Z, Wang Q, Xu Z, Zhang YQ. (2009) Drosophila tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation. Development 136, 1571–1581.

11. Reeve SP, Lin X, Sahin BH, Jiang F, Yao A, Liu Z, Zhi H, Broadie K, Li W, Giangrande A, Hassan BA, Zhang YQ. (2008) Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP. Journal of Neuroscience 28, 3221–3226.

五、招贤纳士

欢迎对研究大脑功能感兴趣、乐于探索、勤于思考、踏实肯干的本科生和研究生加入。